Fabien M. Décaillot Fabien M. Décaillot*,
Postdoctoral Associate

Laboratory of Molecular Biology and Biochemistry
Detlev W. Bronk Building, 502

The Rockefeller University, Box 187
1230 York Avenue
New York, NY 10065

Telephone: 212-327-8283
Fax: 212-327-7904
fdecaillot@rockefeller.edu

Curriculum Vitae

figure 2EDUCATION:

Postdoctoral Researcher, Rockefeller University, New york, NY, 2008 - present
Postdoctoral Researcher, Mount Sinai School of Medicine, New york, NY, , 2003 - 2008
Ph.D. in Molecular Pharmacology, Louis Pasteur University, Strasbourg France, 1998 - 2003
M.S. in Pharmacology, Louis Pasteur University, Strasbourg France, 1997 - 1998
B.S. in Biochemistry, University of Paris VI, Paris France,1992 - 1994








RESEARCH:

Pharmacological implications of GPCR heterodimerization.
Chemokine receptors dimers.
Chemokine receptors belong to the G protein-coupled receptor (GPCR) family implicated in important physiological phenomenon such as immune response, hematopoiesis and HIV infection. Much attention has been dedicated to CXCR4 which also participates in tumor growth and metastasis. Stromal cell-Derived Factor 1 (SDF-1) identified as his main ligand, is a chemokine homoestatically produced in various organs and tissues. Recently the expression of another chemokine receptor (CXCR7) has also been largely linked to cancer development. Moreover CXCR7 was shown to also be able to bind SDF-1 although it was not accompanied by an increase in intracellular Ca2+ nor an inhibition in cAMP production as observed for CXCR4.
We are now investigating a possible heterodimerization between CXCR4 and CXCR7 and its implication in cancer metastasis using a wide range of techniques: coimmunoprecipitation, confocal microscopy imaging, FRET as well as various functional assays such as Secreted Alkaline Phosphatase (SEAP) assay, intracellular Calcium recording, kinases phosphorylation detection and cell migration assays.

AWARDS:

1998- M.E.N.R.T. Fellowship from French Government
2001- A.R.C. (Cancer Research Association) Fellowship
2005- INRC travel award

PUBLISHED PAPERS:

8).
Décaillot F.M., Rozenfeld, R., Gupta A. and Devi L.A.
Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4
Proc. Natl. Acad. Sci. U S A. (2008),105(41):16045-50

PMID: 18836069 [PubMed - indexed for MEDLINE]

7).
Gupta A., Rozenfeld R., Gomes I., Raehal K.M., Décaillot F.M., Bohn L.M., Devi L.A.
Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies.
J. Biol. Chem. (2008), 283:10735-44

PMID: 18256033 [PubMed - indexed for MEDLINE]

6).
Gupta A., Décaillot F.M., Gomes I., Tkalych O., Heimann A.S., Ferro E.S., Devi L.A.
Conformation state sensitive antibodies to G-protein coupled receptors.
J. Biol. Chem. (2007), 282:5116-24

PMID: 17148456 [PubMed - indexed for MEDLINE]

5).
Gupta A., Décaillot F.M. and Devi L.A.
Targeting opioid receptors heterodimers: Strategies for screening and drug development.
A.A.P.S. Journal (2006), 8(1):E153-9

PMID: 16584123 [PubMed - indexed for MEDLINE]
4).
Décaillot F.M., Che F-Y., Fricker L.D. and Devi L.A.
Peptidomics of Cpefat/fat mouse hypothalamus and striatum: Effect of chronic morphine administration.
J. Mol. Neurosci., (2006), 28(3):277-84

PMID: 16691015 [PubMed - indexed for MEDLINE]
3).
Tryoen-Toth P., Décaillot F.M., Filliol D., Befort K., Lazarus L.H., Schiller P.W., Schmidhammer H. and Kieffer B.L.
Inverse agonism and neutral antagonism at wild-type and constitutively active mutant delta opioid receptors.
J. Pharmacol. Exp. Ther. (2005), 1:410-21

PMID: 15590769 [PubMed - indexed for MEDLINE]
2).
Décaillot F.M., Befort K., Filliol D., Yue S., Walker P. and Kieffer B.L.
Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation.
Nat. Struct. Biol. (2003), 10(8):629-36

PMID: 12847517 [PubMed - indexed for MEDLINE]

1).
Befort K., Filliol D., Décaillot F.M., Gav'riaux-Ruff C., Hoehe M. and Kieffer B. L.
A single-nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling.
J. Biol. Chem. (2001),276:3130

PMID: 11067846 [PubMed - indexed for MEDLINE]

RECENT PRESENTATIONS:

1).
Décaillot F.M., Rozenfeld, R., Gupta A. and Devi L.A
Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4
Oral presentation at INRC meeting, Charleston, South Carolina 2008

2).
Décaillot F.M., Befort K., Filliol D., Walker P. and Kieffer B.L.
Delta Opioid Receptor activation by random mutagenesis.
Oral presentation at Neuroscience Meeting, Orlando Florida 2002

POSTERS:

1).
Décaillot F.M., Che F-Y., Fricker L.D. and Devi L.A.
Neuropeptide regulation in mice chronically treated with morphine
Poster presentation at INRC meeting, Annapolis, Maryland 2005

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