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42).
Sakmar, T. P. & Fahmy, K.
Properties and Photoactivity of Rhodopsin Mutants.
Israel J Chem 35:325–338 (1995).
[not indexed for MEDLINE]
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41).
Beck, M., Sakmar, T. P. & Siebert, F.
FTIR Investigations of Rhodopsin and Rhodopsin Mutants in Detergent and Reconstituted into Membranes.
in Sixth European Conference on the Spectroscopy of Biological Molecules (Merlin, J. C., Turrell, S. & Huvenne, J. P., eds.) Kluwer Academic Publishers, Dordrecht, Netherlands, pp. 173–174 (1995).
[not indexed for MEDLINE]
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40).
Fahmy, K., Siebert, F. & Sakmar, T. P.
Molecular Determinants of the Active Conformation of Rhodopsin Studied by Attenuated Total Reflectance FTIR Difference Spectroscopy.
in Sixth European Conference on the Spectroscopy of Biological Molecules (Merlin, J. C., Turrell, S. & Huvenne, J. P., eds.) Kluwer Academic Publishers, Dordrecht, Netherlands, pp. 171–172 (1995).
[not indexed for MEDLINE]
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39).
Unson, C. G., Cypess, A. M., Kim, H. N., Carruthers, C. J. L., Goldsmith, P. K., Merrifield, R. B. & Sakmar, T. P.
Characterization of Deletion and Truncation Mutants of the Rat Glucagon Receptor: Seven Transmembrane Segments Are Necessary for Receptor Transport to the Plasma Membrane and Glucagon Binding.
J Biol Chem 270:27720–27727 (1995).
PMID: 7499239 [PubMed - indexed for MEDLINE]
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38).
Garcia, P. D., Onrust, R., Bell, S. M., Sakmar, T. P. & Bourne, H. R.
Transducin-a Carboxyl-Terminal Mutations Prevent Activation by Rhodopsin: A New Assay Using Recombinant Proteins Expressed in Cultured Cells.
EMBO J 14:4460–4469 (1995).
PMID: 7556089 [PubMed - indexed for MEDLINE]
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37).
Fahmy, K., Siebert, F. & Sakmar, T. P.
The Photoactivated State of Rhodopsin and How It Can Form.
Biophys Chem 56:171–181 (1995).
PMID: 7662864 [PubMed - indexed for MEDLINE]
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36).
Ernst, O., Hofmann, K. P. & Sakmar, T. P.
Characterization of Rhodopsin Mutants That Bind Transducin But Fail To Induce GTP Nucleotide Uptake: Classification of Mutant Pigments by Fluorescence, Nucleotide Uptake, and Light-Scattering Assays.
J Biol Chem 270:10580–10586 (1995).
PMID: 7737995 [PubMed - indexed for MEDLINE]
|
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35).
Carruthers, C. J. L. & Sakmar, T. P.
Synthesis and Expression of Synthetic Genes: Applications to Structure-Function Studies of Receptors.
Methods Neurosci 25:322–344 (1995).
[not indexed for MEDLINE]
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34).
Sakmar, T. P.
Opsins.
in Handbook of Receptors and Channels (Vol. I: G Protein-coupled Receptors) (Peroutka, S. J., ed.) CRC Press, Boca Raton, v. I, pp. 257–276 (1994).
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33).
Fahmy, K., Siebert, F. & Sakmar, T. P.
A Mutant Rhodopsin Photoproduct with a Protonated Schiff Base Displays an Active-state Conformation: a Fourier-Transform Infrared Spectroscopy Study.
Biochemistry 33:13700–13705 (1994).
PMID: 7947779 [PubMed - indexed for MEDLINE]
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32).
Carruthers, C. J. L., Unson, C. G., Kim, H. N. & Sakmar, T. P.
Synthesis and Expression of a Gene for the Rat Glucagon Receptor. Replacement of an Aspartic Acid in the Extracellular Domain Prevents Glucagon Binding.
J Biol Chem 269:29321–29328 (1994).
PMID: 7961903 [PubMed - indexed for MEDLINE]
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31).
Jäger, F., Fahmy, K., Sakmar, T. P. & Siebert, F.
Identification of Glutamic Acid 113 as the Schiff Base Proton Acceptor in the Metarhodopsin II Photointermediate of Rhodopsin.
Biochemistry 33:10878–10882 (1994).
PMID: 7916209 [PubMed - indexed for MEDLINE]
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30).
Arnis, S., Fahmy, K., Hofmann, K. P. & Sakmar, T. P.
A Conserved Carboxylic Acid Group Mediates Light-Dependent Proton Uptake and Signaling by Rhodopsin.
J Biol Chem 269:23879–23881 (1994).
PMID: 7929034 [PubMed - indexed for MEDLINE]
|
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29).
Zyvaga, T. A., Fahmy, K. & Sakmar, T. P.
Characterization of Rhodopsin-Transducin Interaction: A Mutant Rhodopsin Photoproduct with a Protonated Schiff Base Activates Transducin.
Biochemistry 33:9753-9761 (1994).
PMID: 8068654 [PubMed - indexed for MEDLINE]
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28).
Jäger, F., Sakmar, T. P. & Siebert, F.
Molecular Changes of the Membrane-Embedded Car-boxyl Group Glu-122 of Bovine Rhodopsin During the Transition to the Active State Metar-hodopsin II: An Investigation of the Glu-122 to Asp Mutant Using FT-IR Difference Spectros-copy.
in Fifth International Conference on the Spectroscopy of Biological Molecules (Theophanides, T., Anatassopoulou, J. & Fotopoulos, N., eds.) Kluwer Academic Publishers, Dordrecht, Neth-erlands, pp. 223-226 (1993).
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27).
Fahmy, K., Jäger, F., Beck, M., Zyvaga, T. A., Sakmar, T. P. & Siebert, F.
Protonation States of Membrane-Embedded Carboxylic Acid Groups in Rhodopsin and Metarhodopsin II: A Fourier-Transform Infrared Spectroscopy Study of Site-Directed Mutants.
Proc Natl Acad Sci U S A 90:10206–10210 (1993).
PMID: 7901852 [PubMed - indexed for MEDLINE]
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26).
Fahmy, K. & Sakmar, T. P.
Light-Dependent Transducin Activation by an Ultraviolet-Absorbing Rhodopsin Mutant.
Biochemistry 32:9165–9171 (1993).
|
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25).
Fahmy, K. & Sakmar, T. P.
Regulation of the Rhodopsin-Transducin Interaction by a Highly Conserved Carboxylic Acid Group.
Biochemistry 32:7229–7236 (1993).
PMID: 8343512 [PubMed - indexed for MEDLINE].
|
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24).
Min, K. C., Zyvaga, T. A., Cypess, A. M. & Sakmar, T. P.
Characterization of Mutant Rhodopsins Responsible for Autosomal Dominant Retinitis Pigmentosa. Mutations on the Cytoplasmic Surface Affect Transducin Activation.
J Biol Chem 268:9400–9404 (1993).
PMID: 8486634 [PubMed - indexed for MEDLINE]
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23).
Zyvaga, T. A., Min, K. C., Beck, M. & Sakmar, T. P.
Movement of the Retinylidene Schiff Base Counterion in Rhodopsin by One Helix Turn Reverses the pH Dependency of the Metarhodopsin I to Metarhodopsin II Transition.
J Biol Chem 268:4661–4667 (1993). Correction: J Biol Chem 269:13056 (1994).
PMID: 8444840 [PubMed - indexed for MEDLINE]
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22).
Sakmar, T. P., Fahmy, K., Chan, T. & Lee, M.
Mutagenesis Studies of Rhodopsin Phototransduction.
in Structures and Functions of Retinal Proteins (Rigaud, J. L., ed.) Libbey, London, pp. 67-70 (1992).
[not indexed for MEDLINE]
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21).
Sakmar, T. P.
The Traveler's Medical Kit.
Infect Dis Clin North Am 6:355–370 (1992).
PMID: 1624781 [PubMed - indexed for MEDLINE]
|
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20).
Chan, T., Lee, M. & Sakmar, T. P.
Introduction of Hydroxyl-Bearing Amino Acids Causes Bathochromic Spectral Shifts in Rhodopsin: Amino Acid Substitutions Responsible for Red-Green Color Pigment Spectral Tuning.
J Biol Chem 267:9478–9480 (1992).
PMID: 1577792 [PubMed - indexed for MEDLINE]
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Cambridge: |
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19).
Sakmar, T. P., Franke, R. R. & Khorana, H. G.
Mutagenesis Studies of Rhodopsin Phototransduction.
in Signal Transduction in Photoreceptor Cells (Hargrave, P. A., Hofmann, K. P. & Kaupp, U. B., eds.) Springer-Verlag, Berlin, pp. 21–30 (1992).
[not indexed for MEDLINE]
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18).
Lin, S. W., Sakmar, T. P., Franke, R. R., Khorana, H. G. & Mathies, R. A.
Resonance Raman Microprobe Spectroscopy of Rhodopsin Mutants: Effects of Substitutions in the Third Transmembrane Helix.
Biochemistry 31:5105–5111 (1992).
[not indexed for MEDLINE]
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17).
Franke, R. R., Sakmar, T. P., Graham, R. M. & Khorana, H. G.
Structure and Function in Rhodopsin. Studies of the Interaction Between the Rhodopsin Cytoplasmic Domain and Transducin.
J Biol Chem 267:14767–14774 (1992).
PMID: 1634520 [PubMed - indexed for MEDLINE]
|
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16).
Sakmar, T. P., Franke, R. R. & Khorana, H. G.
The Role of the Retinylidene Schiff Base Counterion in Rhodopsin in Determining Wavelength Absorbance and Schiff Base pKa.
Proc Natl Acad Sci U S A 88:3079–3083 (1991).
[not indexed for MEDLINE]
|