87).   
Lin, S. W., Han, M., & Sakmar, T. P. 
Analysis of Functional Microdomains of Rhodopsin.
Methods Enzymol 315:116–130 (2000).

PMID: 10736698 [PubMed - indexed for MEDLINE]

86).   
Fahmy, K., Sakmar, T. P., & Siebert, F. 
Structural Determinants of Active Conformation of Rhodopsin: Molecular Biophysics Approaches.
Methods Enzymol 315:178–196(2000).

PMID: 10736702 [PubMed - indexed for MEDLINE]

85).   
Han, M. & Sakmar, T. P.
Assays for the Activation of Recombinant Expressed Opsin by all-trans-Retinals.
Methods Enzymol 315:251–267 (2000).

PMID: 10736707 [PubMed - indexed for MEDLINE]

84).   
Isele, J., Sakmar, T. P. & Siebert, F. 
Rhodopsin Activation Affects the Environment of Specific Neighboring Phospholipids: An FTIR Spectroscopic Study.
Biophys J 79:3063–3071 (2000).

PMID: 11106612 [PubMed - indexed for MEDLINE]

83).   
Min, K. C., Gravina, S. A. & Sakmar, T. P. 
Reconstitution of the Vertebrate Visual Cascade Using Recombinant Transducin Purified from Sf9 Cells.
Protein Expr Purification 20:514–526 (2000).

PMID: 11087692 [PubMed - indexed for MEDLINE]

82).   
Fahmy, K., Sakmar, T. P. & Siebert, F. 
Transducin-dependent Protonation of Glutamic Acid 134 in Rhodopsin.
Biochemistry 39:10607–10612 (2000).

PMID: 10956053 [PubMed - indexed for MEDLINE]

81).   
Unson, C. G., Wu, C. –R., Sakmar, T. P. & Merrifield, R. B.
Selective Stabilization of the High-affinity Binding Conformation of Glucagon Receptor by the Long Splice Variant of Gas.
J Biol Chem 275:21631–21638 (2000).

PMID: 10791965 [PubMed - indexed for MEDLINE]    

80).   
Cormier, E. G., Persuh, M., Thompson, D. A. D., Lin, S. W., Sakmar, T. P., Olson, W. C. & Dragic, T. 
Specific Interaction of CCR5 Amino-terminal Domain Peptides Containing Sulfo-Tyrosines with HIV-1 Envelope Glycoprotein gp120.
Proc Natl Acad Sci U S A 97:5762–5767 (2000).

PMID: 10823934 [PubMed - indexed for MEDLINE]

79).
Dragic, T., Trkola, A., Thompson, D. A. D., Cormier, E. G., Kajumo, F. A., Maxwell, E., Lin, S. W., Ying, W., Smith, S. O., Sakmar, T. P. & Moore, J. P. 
Binding Pocket for a Small Molecule Inhibitor of HIV-1 Entry Within the Transmembrane Helices of CCR5.
Proc Natl Acad Sci U S A 97:5639–5644 (2000).

PMID: 10779565 [PubMed - indexed for MEDLINE]

77).   
Ernst, O. E., Meyer, C., Marin, E. P., Fu, W. –Y., Sakmar, T. P. & Hofmann, K. P. 
Mutation of the Fourth Cytoplasmic Loop of Rhodopsin Affects Binding of Transducin and Peptides Derived from the Carboxyl-terminal Sequences of Transducin a and g Subunits.
J Biol Chem 275:1937–1943 (2000).

PMID: 10636895 [PubMed - indexed for MEDLINE]

76).   
Marin, E. P., Gopala Krishna, A., Zyvaga, T. A., Isele, J., Siebert, F. & Sakmar, T. P.  
The Amino-terminal Region of the Fourth Cytoplasmic Loop of Rhodopsin Modulates Rhodopsin-transducin Interaction.
J Biol Chem 275:1930–1936 (2000).

PMID: 10636894 [PubMed - indexed for MEDLINE]

75).   
Lewis, J. W., Szundi, I., Fu, W. -Y., Sakmar, T. P. & Kliger, D. S. 
pH Dependence of Photolysis Intermediates in the Photoactivation of Rhodopsin Mutant E113Q.
Biochemistry 39:599–606 (2000).

PMID: 10642185 [PubMed - indexed for MEDLINE]

74).   
Sakmar, T. P. 
Rhodopsin Early Receptor Potential Revisited.
Biophys J 77:1189–1190 (1999).

PMID: 10465733 [PubMed - indexed for MEDLINE]
PMCID: PMC1300410

70).   
Kochendoerfer, G. G., Lin, S. W., Sakmar, T. P.& Mathies, R. A. 
How Color Visual Pigments Are Tuned.
Trends Biochem Sci 24:300–305 (1999).

PMID: 10431173 [PubMed - indexed for MEDLINE]

69).   
Simpson, M. M., Ballesteros, J. A., Chiappa, V., Chen, J., Suehiro, M., Hartman, D. S., Godel, T., Snyder, L. A., Sakmar, T. P. & Javitch, J. A.
Dopamine D4/D2 Receptor Selectivity Is Determined by a Divergent Aromatic Microdomain Contained within the Second, Third, and Seventh Membrane-Spanning Segments.
Mol Pharmacol 56:1116–1126 (1999).

PMID: 10570038 [PubMed - indexed for MEDLINE]

68).   
Cypess, A. M., Unson, C. G., Wu, C. –R. & Sakmar, T. P. 
Two Cytoplasmic Loops of the Glucagon Receptor Are Required to Elevate cAMP or Intracellular Calcium.
J Biol Chem 274:19455–19464 (1999).

PMID: 10383462 [PubMed - indexed for MEDLINE]

67).   
Sakmar, T. P. 
Rhodopsin: a Prototypical G Protein-coupled Receptor.
Progr Nucleic Acid Res Mol Biol 59:1–34 (1998).

PMID: 9427838 [PubMed - indexed for MEDLINE]  

66).   
Beck, M., Siebert, F. & Sakmar, T. P. 
Evidence for the Specific Interaction of a Lipid Molecule with Rhodopsin Which Is Altered in the Transition to the Active State Metarhodopsin II.
FEBS Lett 436:304–308 (1998).

PMID: 9801137 [PubMed - indexed for MEDLINE]

65).   
Lin, S. W., Kochendoerfer, G. G., Carroll, K. S., Wang, D., Mathies, R. A. & Sakmar, T. P. 
Mechanisms of Spectral Tuning in Blue Cone Visual Pigments. Visible and Raman Spectroscopy of Blue-Shifted Rhodopsin Mutants.
J Biol Chem 273:24583–24591 (1998).

PMID: 9733753 [PubMed - indexed for MEDLINE]  

64).   
Beck, M., Sakmar, T. P. & Siebert, F. 
Spectroscopic Evidence for Interaction Between Transmembrane Helices 3 and 5 in Rhodopsin.
Biochemistry 37:7630–7639 (1998).

PMID: 9585578 [PubMed - indexed for MEDLINE]

63).   
Han, M., Smith, S. O. & Sakmar, T. P. 
Constitutive Activation of Opsin by Mutation of Methionine 257 on Transmembrane Helix 6.
Biochemistry 37:8253–8261 (1998).

PMID: 9609722 [PubMed - indexed for MEDLINE]

62).   
Dragic, T., Trkola, A., Lin, S. W., Nagashima, K., Kajumo, F., Allaway, G., Wu, L., MacKay, C., Sakmar, T. P., Maddon, P. J. & Moore, J. P. 
N-Terminal Substitutions in the CCR5 Co-receptor Impair gp120 Binding and HIV-1 Entry.
J Virol 72:279–284 (1998).

PMID: 9420225 [PubMed - indexed for MEDLINE]

61).   
Han, M., Groesbeek, M., Smith, S. O. & Sakmar, T. P. 
The Role of the C9-Methyl Group in Rhodopsin Activation: Characterization of Mutant Opsins with the Artificial Chromophore 11-cis-9-demethyl-Retinal.
Biochemistry 37:538–545 (1998).

PMID: 9425074 [PubMed - indexed for MEDLINE]

60).   
Donzella, G. A., Schols, D., Lin, S. W., Esté, J. A., Nagashima, K. A., Maddon, P. J., Allaway, G. P., Sakmar, T. P., Henson, G., De Clercq, E. & Moore, J. P. 
AMD3100, a Small Molecule Inhibitor of HIV-1 Entry via the CXCR4 Co-receptor.
Nature Med 4:72–77 (1998).

PMID: 9427609 [PubMed - indexed for MEDLINE]

57).   
Han, M., Groesbeek, M., Sakmar, T. P. & Smith, S. O.
The C9-Methyl Group of Retinal Interacts with Glycine 121 in Rhodopsin.
Proc Natl Acad Sci U S A 94:13442–13447 (1997).

PMID: 9391044 [PubMed - indexed for MEDLINE]

56).   
Jäger, S., Han, M., Lewis, J. W., Szundi, I., Sakmar, T. P. & Kliger, D. S. 
Properties of Early Photolysis Intermediates of Rhodopsin Are Regulated by Glycine 121 and Phenylalanine 261.
Biochemistry 36:11804–11810 (1997).

PMID: 9305971 [PubMed - indexed for MEDLINE]

54).   
Jäger, S., Lewis, J. W., Zyvaga, T. A., Szundi, I., Sakmar, T. P. & Kliger, D. S. 
Chromophore Structural Changes in Rhodopsin From Nanoseconds to Microseconds Following Pigment Photolysis.
Proc Natl Acad Sci U S A 94:8557–8562 (1997).

PMID: 9238015 [PubMed - indexed for MEDLINE]

53).   
Sheih, T., Han, M., Sakmar, T. P. & Smith, S. O. 
The Steric Trigger in Rhodopsin Activation.
J Mol Biol 269:373–384 (1997).

PMID: 9199406 [PubMed - indexed for MEDLINE]

52).   
Jäger, S., Lewis, J. W., Zyvaga, T. A., Szundi, I., Sakmar, T. P. & Kliger, D. S. 
Time-resolved Spectroscopy of the Early Photolysis Intermediates of Rhodopsin Schiff Base Counterion Mutants.
Biochemistry 36:1999–2009 (1997).

PMID: 9047297 [PubMed - indexed for MEDLINE]

51).
Kazmi, M. A., Sakmar, T. P. & Ostrer, H. 
Mutation of a Conserved Cysteine in the X-linked Cone Opsins Disrupts Targeting and Causes Color Vision Deficiencies.
Invest Ophthalmol Vis Sci 38:1074–1081 (1997). [*Cover Article]

PMID: 9152227 [PubMed - indexed for MEDLINE]

49).   
Fahmy, K., Zyvaga, T. A., Sakmar, T. P. & Siebert, F. 
Spectroscopic Evidence for Altered Chromophore-Protein Interactions in Low Temperature Photoproducts of the Visual Pigment Responsible for Congenital Night Blindness.
Biochemistry 35:15065–15073 (1996).

MID: 8942673 [PubMed - indexed for MEDLINE]         
 

48).   
Han, M., Lin, S. W., Minkova, M., Smith, S. O. & Sakmar, T. P. 
Functional Interaction of Transmembrane Helices 3 and 6 in Rhodopsin. Replacement of Phenylalanine 261 by Alanine Causes Reversion of Phenotypes of Glycine 121 Replacement Mutants.
J Biol Chem 271:32337–32342 (1996).

PMID: 8943296 [PubMed - indexed for MEDLINE]

47).   
Han, M., Lin, S. W., Smith, S. O. & Sakmar, T. P. 
The Effects of Amino Acid Replacements of Glycine 121 on Transmembrane Helix 3 of Rhodopsin.
J Biol Chem 271:32330–32336 (1996).

PMID: 8943295 [PubMed - indexed for MEDLINE]

46).   
Sheikh, S., Zyvaga, T. A., Lichtarge, O., Sakmar, T. P. & Bourne, H. R.
Rhodopsin Activation Blocked by Metal-Ion-Binding Sites Linking Transmembrane Helices C and F.
Nature 383:347–350 (1996).

PMID: 8848049 [PubMed - indexed for MEDLINE]

45).   
Lin, S. W. & Sakmar, T. P. 
Specific Tryptophan UV-Absorbance Changes Are Probes of the Transition of Rhodopsin to Its Active State.
Biochemistry 35:11149–11159 (1996).

PMID: 8780519 [PubMed - indexed for MEDLINE] .

44).
Zyvaga, T. A., Fahmy, K., Siebert, F. & Sakmar, T. P. 
Characterization of the Mutant Visual Pigment Responsible for Congenital Night Blindness: a Biochemical and Fourier-Transform Infrared Spectroscopy Study.
Biochemistry 35:7536–7545 (1996).

PMID: 8652533 [PubMed - indexed for MEDLINE]