119 116).    
Ludeke, S., Beck, M., Yan, E. C., Sakmar, T. P., Siebert, F. & Vogel, R.
The Role of Glu181 in the Photoactivation of Rhodopsin.
J Mol Biol 353:345–356 (2005).

PMID: 16169009 [PubMed - indexed for MEDLINE] 


Cover114

114).
Sakmar, T. P.
Twenty Years of the Magnificent Seven.
The Scientist 19:22-23 (2005). [*Cover Article]

[not indexed for MEDLINE]


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112).    
Yan, E. C., Ganim, Z., Kazmi, M. A., Chang, B. S. W., Sakmar, T. P. & Mathies, R. A.
Resonance Raman Analysis of the Mechanism of Energy Storage and Chromophore Distortion in the Primary Visual Photoproduct.
Biochemistry 43:10867–10876 (2004).

PMID: 15323547 [PubMed - indexed for MEDLINE]


111

111).
Lewis, J. W., Szundi, I., Kazmi, M. A., Sakmar, T. P. & Kliger, D. S.
Time-Resolved Photointermediate Changes in Rhodopsin Glu181 Mutants.
Biochemistry 43:12614–12621 (2004).

PMID: 15449951 [PubMed - indexed for MEDLINE]


110

110).    
Billick, E., Seibert, C., Pugach, P., Ketas, T., Trkola, A., Endres, M. J., Murgolo, N. J., Coates, E., Reyes, G. R., Baroudy, B. M., Sakmar, T. P., Moore, J. P. & Kuhmann, S. E.
The Differential Sensitivity of Human and Rhesus Macaque CCR5 to Small-Molecule Inhibitors of Human Immunodeficiency Virus Type 1 Entry Is Explained by a Single Amino Acid Difference and Suggests a Mechanism of Action for These Inhibitors.
J Virol 78:4134–4144 (2004).

PMID: 15047829 [PubMed - indexed for MEDLINE]


106

106). 
Yan, E. C., Kazmi, M. A., Ganim, Z., Hou, J. M., Pan, D., Chang, B. S. W., Sakmar, T. P. & Mathies, R. A.
Retinal Counterion Switch in the Photoactivation of the G Protein-Coupled Receptor Rhodopsin.
Proc Natl Acad Sci U S A 100:9262–9267 (2003).

[*See commentary: Birge, R. R. & Knox, B. E. Perspectives on the Counterion Switch-Induced Photoactivation of the G Protein-Coupled Receptor Rhodopsin. Proc Natl Acad Sci U S A 100:9105–9107 (2003).]

PMID: 12835420 [PubMed - indexed for MEDLINE]


105

105). 
Tsamis, F., Gavrilov, S., Kajumo, F., Seibert, C., Kuhmann, S., Ketas, T., Trkola, A., Palani, A., Clader, J. W., Tagat, J. R., McCombie, S., Baroudy,B., Moore, J. P., Sakmar, T. P. & Dragic, T.
Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry.
J Virol 77:5201–5208 (2003).

PMID: 12692222 [PubMed - indexed for MEDLINE]


103

103).   
Seibert, C., Cadene, M., Sanfiz, A., Chait, B. T. & Sakmar, T. P.
Tyrosine Sulfation of CCR5 N-Terminal Peptide by Tyrosylprotein Sulfotransferases 1 and 2 Follows a Discrete Pattern and Temporal Sequence.
Proc Natl Acad Sci U S A 99:11031–11036 (2002).

PMID: 12169668 [PubMed - indexed for MEDLINE]


102

102). 
Unson, C. G., Wu, C. –R., Yoo, B., Cheung, C., Jiang, Y., Sakmar, T. P. & Merrifield, R. B.
The Roles of Specific Extracellular Domains of the Glucagon Receptor in Ligand Binding and Signaling.
Biochemistry 41:11795–11803 (2002).

PMID: 12269822 [PubMed - indexed for MEDLINE]


102

101).
De, S. & Sakmar, T. P.
Interaction of A2E with Model Membranes. Implications to the Pathogenesis of Age-Related Macular Degeneration.
J Gen Physiol 120:147–157 (2002).

PMID: 12149277 [PubMed - indexed for MEDLINE]


100

100).
Gopala Krishna, A., Menon, S. T., Terry, T. J.& Sakmar, T. P.
Evidence That Helix 8 of Rhodopsin Acts As a Membrane-Dependent Conformational Switch.
Biochemistry 41:8298–8309 (2002).

PMID: 12081478 [PubMed - indexed for MEDLINE]


99).
Chang, B. S. W., Jönsson, K., Kazmi, M. A.,
Donoghue, M. J. & Sakmar, T. P.
Recreating a Functional Ancestral Archosaur Visual Pigment.
Mol Biol Evol 19:1483–1489 (2002). [*Rated “EXCEPTIONAL” by the Faculty of 1000]

PMID: 12200476 [PubMed - indexed for MEDLINE]


98

98).
Marin, E. P., Gopala Krishna, A. & Sakmar, T. P.
Disruption of the a5 Helix of Transducin Impairs Rhodopsin-Catalyzed Nucleotide Exchange.
Biochemistry 41:6988–6994 (2002).

PMID: 12033931 [PubMed - indexed for MEDLINE]


97

97).
Yan, E. C., Kazmi, M. A., De, S., Chang, B. S. W., Seibert, C., Marin, E. P.,
Mathies, R. A. & Sakmar, T. P.
Function of Extracellular Loop 2 in Rhodopsin: Glutamic Acid 181 Modulates Stability and Absorption Wavelength of Metarhodopsin II.
Biochemistry 41:3620–3627 (2002).

PMID: 11888278 [PubMed - indexed for MEDLINE]


96).    
Sakmar, T. P.

The Structure of Rhodopsin and the Superfamily of Seven-Helical Receptors: The Same and Not the Same.
Curr Opin Cell Biol 14:189–195 (2002).

PMID: 11891118 [PubMed - indexed for MEDLINE]


94

94).   
Chang, B. S. W., Kazmi, M. & Sakmar, T. P.
Synthetic Gene Technology: Applications to Ancestral Gene Reconstruction and Structure-Function Studies of Receptors.
Methods Enzymol 343:274–294 (2002).

PMID: 11665573 [PubMed - indexed for MEDLINE]       


93

93).   
Jiang, Y., Cypess, A. M., Muse, E. D., Wu, C-. R., Unson, C. G., Merrifield, R. B. & Sakmar, T. P.
Glucagon Receptor Activates Extracellular Signal-Regulated Protein Kinase (ERK) 1/2 via cAMP-Dependent Protein Kinase.
Proc Natl Acad Sci U S A 98:10102–10107 (2001).

PMID: 11517300 [PubMed - indexed for MEDLINE]


Cover92

92).   
Menon, S. T., Han, M. & Sakmar, T. P.
Rhodopsin: Structural Basis of Molecular Physiology.
Physiol Revs 81:1659–1688 (2001). [*Cover Article]

PMID: 11581499 [PubMed - indexed for MEDLINE]


91

91).   
Marin, E. P., Krishna, A. G.
& Sakmar, T. P.
Rapid Activation of Transducin by Mutations Distant From the Nucleotide-Binding Site: Evidence for a Mechanistic Model of Receptor-Catalyzed Nucleotide Exchange by G Proteins.
J Biol Chem 276:27400–27405 (2001).

PMID: 11356823 [PubMed - indexed for MEDLINE]


91

90).   
Marin, E. P., Krishna, A. G., Archambault, V., Simuni, E., Fu, W. Y. & Sakmar, T. P.
The Function of Interdomain Interactions in Controlling Nucleotide Exchange Rates in Transducin.
J Biol Chem 276:23873–23880 (2001).

PMID: 11290746 [PubMed - indexed for MEDLINE]