152 152).
Tchernychev, B., Ren, Y., Sachdev, P., Janz, J.M., Haggis, L., O'Shea, A., McBride, E., Looby, R., Deng, Q., McMurry, T., Kazmi, M.A., Sakmar, T.P., Hunt, S 3rd & Carlson, K.E.
Discovery of a CXCR4 Agonist Pepducin That Mobilizes Bone Marrow Hematopoietic Cells.
Proc Natl Acad Sci U S A 107:22255–22259 (2010). PMID: 21139054, PMCID: PMC3009824
[*Rated "MUST READ" by the Faculty of 1000 Biology]
151

151).
Zaitseva, E., Saavedra, M., Banerjee, S., Sakmar, T. P. & Vogel R.
SEIRA Spectroscopy on a Membrane Receptor Monolayer Using Lipoprotein Particles as Carriers.
Biophys J 99:2327–2335 (2010). PMID: 20923668
150

150).
Kapoor, N., Gupta, R., Menon, S.T., Folta-Stogniew, E., Raleigh, D.P. & Sakmar, T. P.
Nucleobindin 1 Is a Calcium Regulated Guanine Nucleotide Dissociation Inhibitor of G{alpha}i1.
J Biol Chem 285:31647–31660 (2010). PMID: 20679342
149

149).
Sakmar, T. P.
Examining Receptor Activation: New technologies reveal how G protein-coupled receptors recognize ligands and talk to intracellular partners.
Eur Pharm Rev 3:49–53 (2010).
148 148).
Hou, H.J.M. & Sakmar, T. P.
Methodology of Pulsed Photoacoustics and Its Application to Probe Photosystems and Receptors.
Sensors 10:5642–5667 (2010).
PMID: 22219680 [PubMed - indexed for MEDLINE]
147 147).        
Ye, S., Zaitseva, E., Caltabiano, G., Schertler, G. F. X., , Sakmar, T. P., Deupi, X. & Vogel, R. 
Tracking G Protein-coupled Receptor Activation Using Genetically Encoded Infrared Probes.
Nature   464:1386-1389 (2010).
PMID: 20383122 [PubMed - indexed for MEDLINE]
[*Rate "RECOMMENDED" by the Faculty of 1000 Biology]
146 146).        
Miller, J., Agarwal, A., Devi, L. A., Fontanini, K., Hamilton, J. A., Pin, J. P., Shields, D. C., Spek, C. A., Sakmar, T. P., Kuliopulos, A. & Hunt, S. W., 3rd. 
Insider Access:  Pepducin Symposium Explores a New Apprach to GPCR Modulation.
Ann N Y Acad Sci  1180:E1–E12 (2009).
PMID:19925639 [PubMed - indexed for MEDLINE]
145 145).        
Ahuja, S., Eilers, M., Hirshfeld, A., Yan, E. C. –Y., Ziliox, M., Sakmar, T. P., Sheves, M. & Smith, S. O. 
6-s-cis Conformation and Polar Binding Pocket of the Retinal Chromophore in the Photoactivated State of Rhodopsin. 
J Am Chem Soc 131:15160–15169 (2009).
PMID: 19795853 [PubMed - indexed for MEDLINE]
144

144).        
Kapoor, N., Menon, S. T., Chauhan, R., Sachdev, P., & Sakmar, T. P. 
Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins. 
J Mol Biol  393:882–897 (2009).
PMID: 19703466 [PubMed - indexed for MEDLINE]
143 143).
Ye, S., Huber, T., Vogel, R. & Sakmar, T. P.
FTIR Analysis of GPCR Activation using Azido Probes.
Nat Chem Biol 5:397–399 (2009).
PMID: 19396177 [PubMed - indexed for MEDLINE]
139 139).
Seibert, C., Veldkamp, C.T., Peterson, F.C., Chait, B.T., Volkman, B.F. & Sakmar, T.P.
Sequential Tyrosine Sulfation of CXCR4 by Tyrosylprotein Sulfotransferases.
Biochemistry 47:11251–11262 (2008). [*Ranked 19th Most Downloaded Article in Biochemistry Dec. 2008]

PMID: 18834145 [PubMed - indexed for MEDLINE]
139

138).    
Huber, T., Menon, S. & Sakmar, T. P.
Structural Basis for Ligand Binding and Specificity in Adrenergic Receptors: Implications for GPCR-Targeted Drug Discovery.
Biochemistry 47:11013–11023 (2008).
[*Ranked Most Downloaded Article in Biochemistry Oct. – Dec. 2008; 10th Most Downloaded for past 12 months, Feb. – Mar. 2009; 16th Most Downloaded for past 12 months April – May 2009]

PMID: 18821775 [PubMed - indexed for MEDLINE]

Cover137

137).  
Veldkamp, C. T., Seibert, C., Peterson, F. C., De la Cruz, N. B., Haugner, III, J. C., Basnet, H., Sakmar, T. P. & Volkman, B. F.
Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12.
Sci Signal 1:ra4 (2008). [*Cover Article]

PMID: 18799424 [PubMed - indexed for MEDLINE]

136

136).        
Vogel, R., Mahalingam, M., Lüdeke, S., Huber, T., Siebert, F. & Sakmar, T. P.
Functional Role of the “Ionic Lock” – an Interhelical Hydrogen-bond Network in Family A Heptahelical Receptors.
J Mol Biol 380:648–655 (2008).

PMID: 18554610 [PubMed - indexed for MEDLINE]

136

134).
Banerjee, S., Huber, T. & Sakmar, T. P.
Rapid Incorporation of Functional Rhodopsin into Nanoscale Apolipoprotein Bound Bilayers (NABB) Particles.
J Mol Biol 377:1067–1081 (2008).

PMID: 18313692 [PubMed - indexed for MEDLINE]

133

133).        
Louis, M., Huber, T., Benton, R., Sakmar, T. P. & Vosshall, L. B.
Bilateral Olfactory Senstory Input Enhances Chemotaxis Behavior.
Nat Neurosci 11:187–199 (2008).

PMID: 18157126 [PubMed - indexed for MEDLINE]

136

132).   
Ye, S., Köhrer, C., Huber, T., Kazmi, M., Sachdev, P., Yan, E. C., Bhagat, A., Rajbhandary, U. L. & Sakmar, T. P.
Site-specific Incorporation of Keto Amino Acids into Functional G Protein-coupled Receptors Using Unnatural Amino Acid Mutagenesis.
J Biol Chem 283:1525–1533 (2008).

PMID: 17993461 [PubMed - indexed for MEDLINE]

136 130).        
Janz, J. M., Sakmar, T. P. & Min, K. C.
A Novel Interaction Between AIP4 and bPIX Is Mediated by an SH3 Domain.
J Biol Chem 282:28893–28903 (2007).

PMID: 17652093 [PubMed - indexed for MEDLINE]

129

129).       
Periole, X., Huber, T., Marrink, S. J. & Sakmar, T. P.
G Protein-coupled Receptors Self-assemble in Dynamics Simulations of Model Bilayers.
J Am Chem Soc 129:10126–10132 (2007).

PMID: 17658882 [PubMed - indexed for MEDLINE]

128

128).       
Sachdev, P., Menon, S., Kastner, D. B., Chuang, J. Z., Yeh, T. Y., Conde, C., Caceres, A., Sung, C. H. & Sakmar, T. P.
 G Protein bg Sununit Interaction with the Dynein Light-Chain Component Tctex-1 Regulates Neurite Outgrowth.
EMBO J 26:2621–2632 (2007).

PMID: 17491591 [PubMed - indexed for MEDLINE]

127

127).
Yan, E. C., Epps., J., Lewis, J. W.Szundi, I., Bhagat, A., Sakmar, T. P. & Kliger, D. S.
Photointermediates of the Rhodopsin S186A Mutant As a Probe of the Hydrogen Bond Network in the Chromophore Pocket and the Mechanism of Counterion Switch.
J Phys Chem C 111:8843–8848 (2007).

[not indexed for MEDLINE]

126

126).        
Vogel, R., Sakmar, T. P., Sheves, M. & Siebert, F.
Coupling of Protonation Switches During Rhodopsin Activation.
Photochem Photobiol 83:286–292 (2007).

PMID: 17576345 [PubMed - indexed for MEDLINE]

125 125).        
Botelho, A. V., Huber, T., Peterson, F. C., Sakmar, T. P. & Brown, M. F.
Curvature and Hydrophobic Forces Drive Oligomerization and Modulate Activity of Rhodopsin in Membranes.
Biophys J 91:4464–4477 (2006).

PMID: 17012328 [PubMed - indexed for MEDLINE]
123

123).       
Vogel, R., Siebert, F., Yan, E. C., Sakmar, T. P., Hirshfeld, A. & Sheves, M.
Modulating Rhodopsin Receptor Activation by Altering the pKA of the Retinal Schiff Base.
J Am Chem Soc 128:10530–10512 (2006).

PMID: 16895417 [PubMed - indexed for MEDLINE]

122

122).       
Veldkamp, C. T., Seibert, C., Peterson, F. C., Sakmar, T. P. & Volkman, B. F.
Recognition of a CXCR4 Sulfotyrosine by the Chemokine Stromal Cell-derived Factor-1a (SDF-1a/CXCL12).
J Mol Biol 359:1400–1409 (2006).

PMID: 16725153 [PubMed - indexed for MEDLINE]

121

121).    
Lewis, J. W., Szundi, I., Kazmi, M. A., Sakmar, T. P. & Kliger, D. S.
Proton Movement and Photointermediate Kinetics in Rhodopsin Mutants.
Biochemistry 45:5430–5439 (2006).

PMID: 16634624 [PubMed - indexed for MEDLINE]

120

120).   
Su, C. –Y., Luo, D. –G., Terakita, A., Shichida, Y., Liao, H. –W., Kazmi, M., Sakmar, T. P. & Yau, K. –W.
Parietal-Eye Phototransduction Components: Insight into Vertebrate Photoreceptor Evolution.
Science 311:1617–1621 (2006).

PMID: 16543463 [PubMed - indexed for MEDLINE]

119

119).    
Hoelz, A., Janz, J. M., Lawrie, S. D., Corwin, B., Lee, A. & Sakmar, T. P.
Crystal Structure of the SH3 Domain of bPIX in Complex with a High Affinity Peptide from PAK2.
J Mol Biol 358:509–522 (2006).

PMID: 16527308 [PubMed - indexed for MEDLINE]
118

118).
Seibert, C., Ying, W., Gavrilov, S., Tsamis, F., Kuhmann, S. E., Palani, A., Tagat, J. R., Clader, J. W., McCombie, S. W., Baroudy, B. M., Smith, S. O., Dragic, T., Moore, J. P. & Sakmar, T. P.
Interaction of Small Molecule Inhibitors of HIV-1 Entry with CCR5.
Virology 349:41–54 (2006).

PMID: 16494916 [PubMed - indexed for MEDLINE]

117

117).    
Vogel, R., Ludeke, S., Siebert, F., Sakmar, T. P., Hirshfeld, A. & Sheves, M.
Agonists and Partial Agonists of Rhodopsin: Retinal Polyene Methylation Affects Receptor Activation.
Biochemistry 45:1640–1652 (2006).

PMID: 16460011 [PubMed - indexed for MEDLINE]